The COVID-19 pandemic has clearly emphasized the need for understanding how data and evidence drive decision-making across all areas of society. High-quality trustworthy data that is used ethically is essential to support policy and practice decisions that can influence the health of the population. The overarching goal of this project was to co-design an Open Educational Resource (OER) focused on using data to drive decision-making in health by engaging with a team of academics, practitioners, and students. There are five chapters: Chapter 1. Data Literacy--Chapter 2. Data for Equity?--Chapter 3. Implementing Change – Easier Said Than Done--Chapter 4. Knowledge Translation and Exchange to Support Decision-Making--Chapter 5. Using Health Economic Evidence to Inform Decisions About Resource Allocation. The diversity of chapters in this book truly highlights that it takes an integrated approach to drive change in the health sector. This OER Pressbook is interactive with the hopes to prompt critical thinking and reflection to help shape the current and next generation of health professionals.